CJC-1295 No DAC (Mod GRF 1-29) – Lyophilized Peptide

Price range: $40.00 through $70.00

CJC-1295 (No DAC), also known as Modified GRF 1-29, is a synthetic, tetrasubstituted analog of Growth Hormone-Releasing Hormone (GHRH). It is engineered with four amino acid substitutions to prevent rapid degradation by DPP-IV enzymes while maintaining a short half-life. This makes it the premier peptide for researching natural, pulsatile growth hormone secretion in in-vitro pituitary models. Our lyophilized preparation is HPLC-verified for >99% purity. Strictly for laboratory research use only; not for human consumption.

Description

Product Overview In endocrine research, controlling the duration of receptor activation is critical. CJC-1295 (No DAC) represents a highly refined version of the shortest fully functional GHRH fragment (amino acids 1-29). By omitting the Drug Affinity Complex (DAC), this peptide avoids continuous receptor activation, preventing pituitary receptor downregulation.

Mechanism of Action

  • Pituitary Stimulation: It acts directly on the anterior pituitary gland to stimulate the secretion of endogenous growth hormone.

  • Pulsatile Kinetics: With a physiological half-life of approximately 30 minutes, it is ideal for studies requiring a simulated “pulse” rather than a sustained baseline elevation.

  • Synergistic Models: Often researched in conjunction with GHRPs (like Ipamorelin) to study the amplification of the hormonal pulse.

Quality Assurance

  • Identity: Modified GRF 1-29 (Tetrasubstituted)

  • Purity: >99% Verified by HPLC

  • Form: Sterile White Lyophilized Powder

Disclaimer:

WARNING – FOR RESEARCH USE ONLY: This product is sold exclusively as an analytical reference standard and research chemical. It is NOT an FDA-approved drug or medical device. Not for human consumption, therapeutic use, or veterinary application. Any reference to physiological effects is strictly for educational context.

Additional information

MG

5, 10

Research reference

A tetrasubstituted analogue of growth hormone releasing hormone (1-29), also known as Mod GRF 1-29, with amino-acid substitutions that increase stability against enzymatic degradation. Used in GHRH receptor research.

Class
GHRH (1-29) analogue
CAS
863288-34-0
Formula
C152H252N44O42
Storage
Lyophilized: -20°C. Reconstituted: 2-8°C.

Research use only. Sold as a chemical reference standard for in-vitro laboratory research. Not for human or veterinary use, and not a drug, food or cosmetic.